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Recruitment : uveal melanoma post doctoral researcher

SIRIC team
08/24/2020
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A post at the Institut Curie Research Center
Protein MBD4 PDB 1ngn

The DNA Repair and Uveal Melanoma team (D.R.U.M), Inserm U830, led by Marc-Henri Stern, are looking for a post doctoral research to develop research on a new genomic instability pathway found in uveal melanoma. The post is to be filled immediately. 

Research project

Uveal melanoma (UM) is the most common eye cancer in adults. Despite improved treatment of the primary tumor, there is no effective treatment of metastatic disease.

The D.R.U.M team mainly works on the genetics and genomics of primary and metastatic UM.  Over the past few years, the team have identified SF3B1 as a novel driver in UM, showed the low tumor burden and absence of UV mutation signature, and unraveled the role of mutant SF3B1 on aberrant splicing.

More recently, we identified MBD4 as an important actor in UM. MBD4 deficient UM display an atypical signature with a high tumor burden and are responsive to immune checkpoint inhibitors. Germline mutations of MBD4 explain genetic predisposition to UM. 

Although the role of MBD4 in UM is now established, its molecular function and dysfunction in diseases remain poorly characterized. The post-doc project will aim to characterize the function of MBD4, the consequences of its inactivation in tumors, and to improve the treatments of MBD4-inactivated tumors. For this, we have access to one of the largest biobank world-wide for UM primary and metastatic samples, a collection of UM patient-derived xenografts (PDXs) and UM cell lines, including MBD4 proficient and deficient tumors and isogenic cell lines.

This research project is part of a translational research project in collaboration with the Institut Curie hospital, the and the Institut du Cerveau et de la Moelle (ICM, hospital Pitié-Salpêtrière) and is financed by the Institut National du Cancer (INCa)

Required profile

  • The applicant should hold a PhD in biology
  • Be trained in cellular and molecular techniques with a good publication record in related fields
  • Knowledge in cancer biology and in DNA repair will be highly appreciated.
  • Bioinformatics training is not mandatory.

Send your candidature (CV, cover letter and references) by email to Marc-Henri Stern, Inserm U830 (see contact block in right-hand column). 

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