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Identification of a fibroblast subset associated with relapse in luminal breast cancer

The study of mechanisms associated with metastatic disease pave the way for new therapeutic perspectives
Breast Cancer Research (BMC)

Luminal breast cancer prognosis is generably favorable but a non-negligeable percentage of patients relapse. Being able to identify these cases before the relapse appears would have an important impact on treatment of the disease. 

In this context, Bonneau et al carried out a detailed analysis of tumor cell characteristics associated with distant relapse in patients with luminal breast cancer. They show that a subset of cancer associated fibroblasts (CAFs) accumulate significantly in tumors with distant relapse

These results could help identify tumors with a high risk of relapse. 

Associated publications :

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Examen sein
Breast cancers

Breast cancer is the most common malignant tumor in women with around 50 000 new cases diagnosed each year in France…